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Not to mention, creatine also raises levels of IGF-1 (insulin-like growth factor), a hormone that promotes muscle growth (32)and IGF-1's beneficial role in the prevention and treatment of cardiovascular disease (33). One study found that a 1-month supplement of creatine monohydrate and a combined L-dopa and creatine complex reduced mortality from heart failure (34). 4. Supplementation of 1 g L-dopa daily (15 mg/kg bodywt) for 2 weeks significantly improved memory functions, as measured in a neuropsychological test battery (35). However, the study was done in elderly volunteers and the improvement was not statistically significant (35). 5. Two weeks supplementation of 1 g L-dopa daily reduces cognitive impairment in young and old healthy adults (36). A previous study showed that creatine was effective in protecting against cognitive decline (37). 6. Creatine supplementation significantly improves cognitive function and prevents memory loss in Alzheimer's disease, with doses of 25 and 50 mg/kg/day (38). 7. Supplementation also extends life span and increases muscle mass in young adults (38). 8. Creatine supplementation decreases fatigue and anxiety and extends life span and muscle mass in individuals with multiple sclerosis (39). 9. Supplementation of creatine has been shown to improve cognitive function in patients with moderate to severe bipolar disorder during a 6-year study (40). 10, 11. Supplementation of 1 g L-dopa for 2 weeks (15 mg/kgbodywt) also improved pain intensity at the forearm, knee, shoulder, and ankle joint sites and caused no adverse neuropsychological effects (41). 12. In a study in young men, 12-wk supplementation of 1 g L-dopa and 10 mg Vitamin B-6 caused no significant adverse effects (42). 13. A study in young adults found that supplementation of 5 g creatine monohydrate was effective in improving blood glucose control and cognitive function (42). 14. A study in elderly subjects gave both an oral and an intravenous dose of creatine for 48 hours and there was little or no adverse effect or significant change in cognition for the two dosage levels (43). 15. Supplementation of 1 g L-dopa daily for 4 weeks significantly improved spatial memory and learning abilities in older adults with mild to moderate cognitive impairment (44). 16. There are no significant differences in cognitive performance in older adults following supplementation of 5 g (2 g) L-dopa compared with placebo (45). However, in older subjects receiving 5-g L Similar articles:

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